Average preterm cord values of potassium and chloride were higher than term values.Cord blood electrolyte, creatinine, and glucose values vary across neonatal gestational age.The changes across GA and by delivery mode, SGA, and being a multiple, which may have direct implications for neonatal care and fluid management. Preterm reference values differed from published adults' reference values. Average preterm reference values were higher than term values for potassium and chloride. Cesarean section was associated with higher potassium and lower glucose, multiple births with higher chloride and creatinine and lower glucose, and SGA with lower glucose.Ĭord blood values varied across the GA range with increases in sodium, chloride, and creatinine, while glucose remained steady. 62-115 µmol/L), and more variable for potassium (2.7-7.9 vs. Compared with adult reference intervals, cord preterm reference intervals were higher for chloride (100-111 vs. Average preterm cord potassium and chloride were higher than the term ( p < 0.05). Preterm cord glucose levels were steady (3.7 ± 1.1 mmol/L), while sodium, chloride, and creatinine increased over GA by 0.17, 0.14 mmol/L/week, and 1.07 µmol/L/week, respectively ( p < 0.003). There were 591 infants, 537 preterm and 54 term. Conclusions: Cord blood values varied across the GA range with increases in sodium, chloride, and creatinine, while glucose remained steady. We compared preterm cord values to term, and to adult reference ranges. Cesarean section was associated with higher potassium and lower glucose, multiple births with higher chloride and creatinine and lower glucose, and SGA with lower glucose. We examined associations with gestational age, delivery mode, singleton versus multiple, and prenatal maternal adverse conditions.
We examined cord blood sodium, chloride, potassium, glucose, and creatinine to derive maturity-related reference intervals. In term babies, cord blood values differed in pathological pregnancies from healthy ones. International guidelines recommend that preterm infants should be supported to maintain their serum electrolytes within "normal" ranges.
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